• Product NameSulfatinib
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySulfatinib may be a potent drug for cancer. It inhibits KDR and FGFR1 enzymatic activity, with IC50 values of 0.021 and 0.053 μM, respectively. Also, it is a hERG inhibitor with IC50 of 6.8 μM in CHO cell.
• Target NameFGFR inhibitor; HER inhibitor; VEGFR inhibitor
• CAS No. 1816307-67-1
• Calculated MW 480.59
• Formulation C24H28N6O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC2=C(N1)C=CC(=C2)OC3=NC(=NC=C3)NC4=CC=CC(=C4)CS(=O)(=O)NCCN(C)C
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:FGFR1; hERG; KDR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 30 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. PCT Int. Appl. (2011), WO 2011060746 A1 20110526.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting