• Product NamePE859
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively.
• Target NameGamma-secretase inhibitor; Microtubule Associated inhibitor
• CAS No. 1402727-29-0
• Calculated MW 448.52
• Formulation C28H24N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:COC1=C(C=CC(=C1)OCC2=CC=CC=N2)/C=C/C3=CC(=NN3)/C=C/C4=CC5=C(C=C4)C=CN5
  Pathways:Neuroscience; Cytoskeletal Signaling; Proteases/Proteasome; Stem Cells
  Receptor:Aβ; tau
  Boling pt:
  Melting pt:
  Solubility:DMSO: 30 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.NA

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting