• Product NameLY303511 hydrochloride
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM in cell-free assays, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation.
• Target NamePI3K inhibitor
• CAS No. 934389-88-5
• Calculated MW 342.81
• Formulation C19H19ClN2O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4.Cl
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:p110α; p110β; p110δ
  Boling pt:
  Melting pt:
  Solubility:DMSO Solubility: 36 mg/mL (117.13 mM); Ethanol: 21 mg/mL (68.32 mM); Water: Insoluble;
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chaussade C, et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007 Jun 15;404(3):449-58.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting