• Product NameThymoquinon
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityIt has anti-inflammatory effects, blocking the synthesis of leukotrienes.2,1 Thymoquinone inhibits the growth of leukemia cells (IC50 = 1.5 μg/ml), inducing apoptosis by down-regulating the expression of Bcl-2 while up-regulating Bax expression.3 In addition to blocking cell proliferation and triggering apoptosis, thymoquinone (15 μM) suppresses STAT3-regulated gene expression and prevents angiogenesis.4,5
• Target NameBcr-Abl inhibitor
• CAS No. 490-91-5
• Calculated MW 164.2
• Formulation C10H12O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC(=O)C(=CC1=O)C(C)C
  Pathways:Angiogenesis; Cytoskeletal Signaling
  Receptor:Bcl-2
  Boling pt:
  Melting pt:
  Solubility:Water: soluble
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Randhawa, M.A., and Alghamdi, M.S. Anticancer activity of Nigella sativa (black seed) - A review. Am.J.Chin.Med. 39(6), 1075-1091 (2011).

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting