• Product NamePF-06282999
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases.
• Target NameOthers inhibitor
• CAS No. 1435467-37-0
• Calculated MW 325.77
• Formulation C13H12ClN3O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular system
  SMILES:COC1=C(C=C(C=C1)Cl)C2=CC(=O)NC(=S)N2CC(=O)N
  Pathways:Others
  Receptor:Myeloperoxidase
  Boling pt:
  Melting pt:
  Solubility:DMSO: 32 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Dong JQ, et al. Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans. Drug Metab Dispos. 2016 Feb;44(2):209-19.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting