• Product NameTyrphostin AG 126
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityThe tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vivo, attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 is a poor inhibitor of epidermal GFRK (IC50 = 450 μM) and platelet-derived GFRK (IC50 > 100 μM).
• Target NameCOX inhibitor; ERK inhibitor
• CAS No. 118409-62-4
• Calculated MW 215.168
• Formulation C10H5N3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C1=CC(=C(C=C1C=C(C#N)C#N)O)[N+](=O)[O-]
  Pathways:Immunology/Inflammation; MAPK; Neuroscience
  Receptor:COX-2; ERK1,2
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Novogrodsky, A.,Vanichkin, A.,Patya, M., et al. Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 264(5163), 1319-1322 (1994).

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting