• Product NameAS-8351
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAS-8351 is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.
• Target NameOthers inhibitor
• CAS No. 796-42-9
• Calculated MW 570.69
• Formulation C22H34N8O6S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1=CC=C\2C(=C1)C=CC(=O)/C2=C\NNC(=O)C3=CC=NC=C3
  Pathways:Others
  Receptor:Demethylase
  Boling pt:
  Melting pt:
  Solubility:10 mM in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Cao, N.,Huang, et al.?Conversion of human fibroblasts into functional cardiomyocytes by small molecules.?Science?352(6290),?1216-1220?(2016).

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting