• Product NameAFN-1252
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAFN-1252(Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of 0.12 μg/ml.
• Target NameOthers inhibitor
• CAS No. 620175-39-5
• Calculated MW 375.42
• Formulation C??H??N?O?
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CC1=C(OC2=CC=CC=C12)CN(C)C(=O)/C=C/C3=CC4=C(NC(=O)CC4)N=C3
  Pathways:Others
  Receptor:enoyl-acyl carrier protein reductase (FabI)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 5.8 mg/mL(Need ultrasonic)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Karlowsky JA, et al. AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. Antimicrob Agents Chemother. 2009 Aug;53(8):3544-8.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting