• Product NameMK-8617
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityMK-8617 is an orally active pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1?3 (HIF PHD1?3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively.
• Target NameHIF/HIF Prolyl-Hydroxylase inhibitor
• CAS No. 1187990-87-9
• Calculated MW 443.45
• Formulation C24H21N5O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)NC(=O)C3=CN=C(NC3=O)C4=NN=CC=C4
  Pathways:Metabolism; Chromatin/Epigenetic
  Receptor:PHD1; PHD2; PHD3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 20 mg/mL warmed (45.1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.John S. Debenham, et al. J Med Chem. 2016, 59 (24):11039-11049.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting