- Product NameSB 271046 hydrochloride
- Brief DescriptionInhibitors
- Purification98.00%
- Biological ActivitySelective, orally active 5-HT6 antagonist (pKi values are 9.02-8.92, 6.55, 6.35, 6.27, 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and < 4.99 at 5-HT6, 5-HT1D, 5-HT1A, D3, 5-HT1B, 5-HT1F, α1B, 5-HT2C, 5-HT2A, D2, 5-HT2B, 5-HT7, 5-HT4 and 5-HT1E respectively) and is > 200-fold selective over 55 other receptors, enzymes and ion channels. Increases extracellular glutamate and aspartate in the frontal cortex, and exhibits anticonvulsant activity (EC50 = 0.16 μM).
- Target Name5-HT antagonist
- CAS No. 209481-24-3
- Calculated MW 488.45
- Formulation C20H22ClN3O3S2.HCl
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
