• Product NameLYN-1604
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 could induce cell death, associated with autophagy by the ULK complex (ULK1-mATG13-FIP200-ATG101) in MDA-MB-231 cells.
• Target NameAutophagy inhibitor
• CAS No. 2088939-99-3
• Calculated MW 584.626?
• Formulation C33H43Cl2N3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1=CC=C(C=C1)[C@H](N/C=C/2\N=CC(=O)C=C2)COCC3=CN=C(C=C3)C4=CC=CC=N4.C1=CC=C(C=C1)[C@H](N/C=C/2\N=CC(=O)C=C2)COCC3=CN=C(C=C3)C4=CC=CC=N4.C1=CC=C(C=C1)[C@H](N/C=C/2\N=CC(=O)C=C2)COCC3=CN=C(C=C3)C4=CC=CC=N4.[Cl-].[Cl-].[Cl-].[Cl-].[Fe+2].[Fe+2]
  Pathways:Autophagy
  Receptor:ULK1
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO, not in water
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1: Zhang L, Fu L, Zhang S, Zhang J, Zhao Y, Zheng Y, He G, Yang S, Ouyang L, Liu B. Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem Sci. 2017 Apr 1;8(4):2687-2701.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting