• Product NameOTS964
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityOTS964 is a potent and selective TOPK inhibitor with potential anticancer activity. OTS964 inhibits TOPK kinase activity with high affinity and selectivity. Similar to the knockdown effect of TOPK small interfering RNAs (siRNAs), this inhibitor causes a cytokinesis defect and the subsequent apoptosis of cancer cells in vitro as well as in xenograft models of human lung cancer. Although administration of the free compound induced hematopoietic adverse reactions (leukocytopenia associated with thrombocytosis), the drug delivered in a liposomal formulation effectively caused complete regression of transplanted tumors without showing any adverse reactions in mice.?
• Target NameTOPK inhibitor
• CAS No. 1338545-07-5
• Calculated MW 428.97
• Formulation C23H24N2O2S.HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C[C@H](C1=CC=C(C=C1)C2=C(C=CC3=C2C4=C(C(N3)=O)SC=C4)O)CN(C)C
  Pathways:MAPK
  Receptor:TOPK
  Boling pt:
  Melting pt:
  Solubility:DMSO 85 mg/mL (198.14 mM) Ethanol 1 mg/mL (2.33 mM) Water Insoluble
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Matsuo Y, et al. TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. Sci Transl Med. 2014 Oct 22;6(259):259ra145

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting