• Product NameUCPH-101
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityUCPH-101 is an?excitatory amino acid transporter subtype 1?(EAAT1) inhibitor with an?IC50?of 0.66 μM.
• Target Nametransporter inhibitor
• CAS No. 1118460-77-7
• Calculated MW 422.484
• Formulation C27H22N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:COC1=CC=C(C=C1)C2C(=C(OC3=C2C(=O)CC(C3)C4=CC=CC5=CC=CC=C54)N)C#N
  Pathways:Metabolism
  Receptor:EAAT1
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Abrahamsen B, et al. Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. J Neurosci. 2013 Jan 16;33(3):1068-87.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting