• Product NameRepertaxin
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityReparixin is a potent inhibitor of both CXCL8 receptors?CXCR1/2, it inhibits weakly?CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks?CXCR1-mediated chemotaxis (IC50=1 nM).
• Target NameCXCR inhibitor
• CAS No. 266359-83-5
• Calculated MW 283.39
• Formulation C14H21NO3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC(=C(C(=C1)C)S(=O)(=O)N[C@H](C=O)C(C)C)C
  Pathways:Autophagy; GPCR/G Protein; Immunology/Inflammation
  Receptor:CXCR1; CXCR2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 500 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Moriconi A, et al. Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2. J Med Chem. 2007 Aug 23;50(17):3984-4002.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting