• Product NameB-Raf inhibitor 1 dihydrochloride
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityB-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively.
• Target NameRaf inhibitor
• CAS No. 1191385-19-9
• Calculated MW 478.94
• Formulation C26H19ClN8
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC1=C(C2=C(C=C1)C(=NC=C2)NC3=CC=C(C=C3)Cl)NC4=C(C=CC=N4)C5=C6C(=NC=N5)N=CN6.Cl.Cl
  Pathways:MAPK
  Receptor:B-Raf
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wang X, et al. J Med Chem. 2012 Sep 13;55(17): 7332-41.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting