• Product NamePKM2 inhibitor
• Brief DescriptionInhibitors
• Purification99.68%
• Biological ActivityPKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
• Target NamePKM inhibitor
• CAS No. 94164-88-2
• Calculated MW 345.475
• Formulation C18H19NO2S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC1=C(C(=O)C2=CC=CC=C2C1=O)CSC(=S)N3CCCCC3
  Pathways:Metabolism
  Receptor:PKM1; PKM2
  Boling pt:
  Melting pt:
  Solubility:DMSO 6 mg/mL (17.36 mM) Water Insoluble Ethanol Insoluble
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ning X, et al. Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase. Eur J Med Chem. 2017 Sep 29;138:343-352.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting