• Product NameGemcitabine monophosphate
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGemcitabine monophosphate disodium salt, also called GemMP, is a monophosphate derivative of Gemcitabine. Gemcitabine (Gem) is a deoxycytidine analog that is effective against pancreatic cancer and other malignancies following conversion to the 5'-O-mono-, di- and tri-phosphate forms. GemMP decreased tumor cell growth at concentrations ranging from 1 to 50 nM. GemMP is a potent cytotoxic agent that serves to induce apoptosis in association with increased Fas expression in cultured thyroid cancer cell lines
• Target NameAutophagy; DNA Alkylation; DNA/RNA Synthesis; Others
• CAS No. 1638288-31-9
• Calculated MW 405.15811
• Formulation C9H12F2N3Na2O8P
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:O=C1N=C(N)C=CN1[C@@H]2O[C@H](COP(O[Na])(O[Na])=O)[C@@H](O)C2(F)F.O
  Pathways:Autophagy; DNA Damage/DNA Repair; Others
  Receptor:Autophagy; DNA; Thymidylate synthase; UMP-CMP kinase
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO, not in water
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Miao L, et al. Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer. Adv Funct Mater. 2014 Nov 12;24(42):6601-6611. PubMed PMID: 25395922; PubMed Central PMCID: PMC4225819.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting