• Product NameTAK-659 (hydrochloride)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityTAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.
• Target NameFLT inhibitor; JAK inhibitor; Syk inhibitor; Tyrosine Kinases inhibitor; VEGFR inhibitor
• CAS No. 1952251-28-3
• Calculated MW 380.85
• Formulation C17H22ClFN6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:cancer
  SMILES:CN1C=C(C=N1)C2=NC(=C(C3=C2C(=O)NC3)F)N[C@@H]4CCCC[C@@H]4N.Cl
  Pathways:Angiogenesis; Proteases/Proteasome; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors; JAK/STAT signaling; Stem Cells
  Receptor:FLT3; JAK3; Syk; ZAP70; VEGFR2
  Boling pt:
  Melting pt:
  Solubility:Water 4 mg/mL warmed (10.5 mM) DMSO Insoluble Ethanol Insoluble
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lam B, et al. Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK). Bioorg Med Chem Lett. 2016 Dec 15;26(24):5947-5950.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting