• Product NameSAR-20347
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySAR-20347 is an inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50s of 0.6, 23, 26 and 41 nM, respectively.
• Target NameJAK inhibitor; Tyrosine Kinases inhibitor
• CAS No. 1450881-55-6
• Calculated MW 444.847
• Formulation C21H18ClFN4O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:cancer
  SMILES:C1COCCN1C(=O)C2=CC=C(C=C2)NC3=C(N=C(O3)C4=C(C=CC=C4Cl)F)C(=O)N
  Pathways:Angiogenesis; Proteases/Proteasome; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
  Receptor:JAK1; JAK2; JAK3; TYK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Works MG, et al. Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis. J Immunol. 2014 Oct 1;193(7):3278-87.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting