• Product Name NCT-503
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGilteritinib(ASP2215) is a small-molecule FLT3/AXL inhibitor with IC50 values of 0.29 nM and 0.73 nM for FLT3 and AXL, respectively. It inhibits FLT3 at an IC50 value that was approximately 800-fold more potent than the concentration required to inhibit c-KIT (230 nM).
• Target NameDehydrogenase inhibitor; FLT inhibitor; TAM Receptor inhibitor
• CAS No. 1916571-90-8
• Calculated MW 408.487
• Formulation C20H23F3N4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC1=CC(=NC(=C1)NC(=S)N2CCN(CC2)CC3=CC=C(C=C3)C(F)(F)F)C
  Pathways:Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
  Receptor:PHGDH (Cell-free) ; FLT3; AXL
  Boling pt:
  Melting pt:
  Solubility:DMSO 81 mg/mL (198.29 mM) Ethanol 81 mg/mL (198.29 mM) Water Insoluble
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting