• Product NameSMI-4a
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityTCS-PIM-1-4a is a Pim inhibitor that blocks mTORC1 activity via activation of AMPK; kills a wide range of both myeloid and lymphoid cell lines (with IC50 values ranging from 0.8 to 40 μM).
• Target NamePim inhibitor
• CAS No. 327033-36-3
• Calculated MW 273.229
• Formulation C11H6F3NO2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:cancer
  SMILES:C1=CC(=CC(=C1)C(F)(F)F)/C=C/2\C(=O)NC(=O)S2
  Pathways:Chromatin/Epigenetic; JAK/STAT signaling
  Receptor:Pim 1; Pim 2
  Boling pt:
  Melting pt:
  Solubility:10 mM in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lin YW, et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 ;115(4):824-33.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting