• Product NameML335
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityML335 is a selective activator of both TREK-1 and TREK-2.
• Target NamePotassium Channel activator
• CAS No. 825658-06-8
• Calculated MW 373.248
• Formulation C15H14Cl2N2O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CS(=O)(=O)NC1=CC=C(C=C1)C(=O)NCC2=C(C=C(C=C2)Cl)Cl
  Pathways:Membrane transporter/Ion channel
  Receptor:TREK-1; TREK-2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 155 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lolicato M, et al. K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature. 2017 Jul 20;547(7663):364-368.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting