• Product NameNolatrexed
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityNolatrexed, also known as AG337, is a thymidylate synthase inhibitor with potential anticancer activity.
• Target NameDNA/RNA Synthesis inhibitor
• CAS No. 147149-76-6
• Calculated MW 284.33
• Formulation C14H12N4OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:cancer
  SMILES:CC1=C(C2=C(C=C1)NC(=NC2=O)N)SC3=CC=NC=C3
  Pathways:DNA Damage/DNA Repair
  Receptor:Thymidylate synthase
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO, not in water
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1: Zheng J, et al. Metastatic nasopharyngeal carcinoma outcomes in patients on cisplatin with nolatrexed or 5-fluorouracil. Oncol Res Treat. 2014;37(10):540-4. doi: 10.1159/000368107. Epub 2014 Sep 16. PubMed PMID: 25342504.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting