• Product NameFGF-401
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityFGF401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, FGF401 binds to and inhibits the activity of FGFR4, which leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. FGFR4 is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cell proliferation, differentiation, angiogenesis, and survival.
• Target NameFGFR inhibitor
• CAS No. 1708971-55-4
• Calculated MW 506.567
• Formulation C25H30N8O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:cancer
  SMILES:CN1CCN(C(=O)C1)CC2=C(N=C3C(=C2)CCCN3C(=O)NC4=NC=C(C(=C4)NCCOC)C#N)C=O
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:FGFR4
  Boling pt:
  Melting pt:
  Solubility:DMSO: 6 mg/mL (Need Ultrasonic)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. WO2015059668A1

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting