• Product NameAZD3759 hydrochloride
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAZD3759 (hydrochloride) is a potent, oral active, central nervous system-penetrant,?EGFR?inhibitor. At Km?ATP concentrations, the?IC50s are 0.3, 0.2, and 0.2 nM for EGFRwt, EGFRL858R, and EGFRexon 19Del, respectively.
• Target NameEGFR inhibitor
• CAS No. 1626387-81-2
• Calculated MW 496.36
• Formulation C22H24Cl2FN5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:cancer
  SMILES:C[C@@H]1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C.Cl
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR (exon 19De); EGFR (L858R); EGFR (wt)
  Boling pt:
  Melting pt:
  Solubility:10 mM in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zeng Q, et al. Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor. J Med Chem. 2015 Oct 22;58(20):8200-15.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting