• Product NameMTX-211
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityMTX-211 is a dual inhibitor of?EGFR?and?PI3K, used for the treatment of cancer and other diseases.
• Target NameEGFR inhibitor; PI3K inhibitor
• CAS No. 1952236-05-3
• Calculated MW 478.33
• Formulation C20H14Cl2FN5O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1=NC(Cl)=C(NS(C)(=O)=O)C=C1C1=CC2C(NC3=CC(Cl)=C(F)C=C3)=NC=NC=2C=C1
  Pathways:Angiogenesis; PI3K/Akt/mTOR signaling; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR; PI3K
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Small molecule inhibitors of egfr and pi3k. WO 2016100347 A2

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting