• Product NamePalifosfamide
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPalifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 ro 6.75 μM for most cell lines except OS222 (IC50=31.5 μM)
• Target NameDNA Alkylation inhibitor
• CAS No. 31645-39-3
• Calculated MW 221.02
• Formulation C4H11Cl2N2O2P
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C(CCl)NP(=O)(NCCCl)O
  Pathways:DNA Damage/DNA Repair
  Receptor:DNA alkylator
  Boling pt:
  Melting pt:
  Solubility:DMSO: 42 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Hingorani P, et al. Preclinical activity of palifosfamide lysine (ZIO-201) in pediatric sarcomas including oxazaphosphorine-resistant osteosarcoma. Cancer Chemother Pharmacol. 2009 Sep;64(4):733-40.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting