• Product NameSB-756050
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySB756050 is a selective TGR5 agonist currently in phase 1clinical trials for the treatment of type 2 diabetes.
• Target NameGPCR19 inhibitor
• CAS No. 447410-57-3
• Calculated MW 500.59
• Formulation C21H28N2O8S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:O=S(N1CCN(S(=O)(C2=CC=C(OC)C(OC)=C2)=O)CCC1)(C3=CC=C(OC)C(OC)=C3)=O
  Pathways:GPCR/G Protein
  Receptor:TGR5
  Boling pt:
  Melting pt:
  Solubility:DMSO: 150 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Hodge RJ, et al. Safety, Pharmacokinetics, and Pharmacodynamic Effects of a Selective TGR5 Agonist, SB-756050, in Type 2 Diabetes. Clin Pharmacol Drug Dev. 2013 Jul;2(3):213-22.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting