• Product NameADX88178
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityDX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.
• Target NamemGluR modulator
• CAS No. 1235318-89-4
• Calculated MW 272.33
• Formulation C12H12N6S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC1=NC(NC2=NC(C3=CNN=C3)=C(C)S2)=NC=C1
  Pathways:GPCR/G Protein
  Receptor:human mGluR4
  Boling pt:
  Melting pt:
  Solubility:DMSO: 50 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Fujinaga M, et al. Radiosynthesis and evaluation of 5-methyl-N-(4-[(11)C]methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine ([(11)C]ADX88178) as a novel radioligand for imaging of metabotropic glutamate receptor subtype 4 (mGluR4). Bioorg Med Chem Lett. 2016 Jan 15;26(2):370-4.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting