• Product NameBirinapant
• Brief DescriptionInhibitors
• Purification97.00%
• Biological ActivityBirinapant is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM, less potent to XIAP. Phase 2.
• Target NameIAP inhibitor
• CAS No. 1260251-31-7
• Calculated MW 806.94
• Formulation C42H56F2N8O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC[C@@H](C(=O)N1C[C@H](C[C@H]1CC2=C(NC3=C2C=CC(=C3)F)C4=C(C5=C(N4)C=C(C=C5)F)C[C@@H]6C[C@@H](CN6C(=O)[C@H](CC)NC(=O)[C@H](C)NC)O)O)NC(=O)[C@H](C)NC
  Pathways:Apoptosis
  Receptor:cIAP1; XIAP
  Boling pt:
  Melting pt:
  Solubility:DMSO:100 mg/mL (123.92 mM)Ethanol:55 mg/mL (68.15 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Allensworth JL, et al. Breast Y Res Treat, 2013, 137(2), 359-371.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting