• Product NameFRAX597
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityFRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively.
• Target NamePAK inhibitor
• CAS No. 1286739-19-2
• Calculated MW 558.1
• Formulation C29H28ClN7OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCN1C(=O)C(=CC2=CN=C(NC3=CC=C(C=C3)N3CCN(C)CC3)N=C12)C1=C(Cl)C=C(C=C1)C1=CN=CS1
  Pathways:Cytoskeletal Signaling
  Receptor:PAK1; PAK2; PAK2; PAK3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 14 mg/mL warmed (25.08 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Licciulli S, et al. J Biol Chem. 2013, 288(4), 29105-29114.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting