• Product NameOSI-906 (Linsitinib)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityOSI-906 (Linsitinib) is a selective inhibitor of IGF-1R with IC50 of 35 nM; modestly potent to InsR with IC50 of 75 nM, and no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc. Phase 3.
• Target NameIGF-1R inhibitor; Others inhibitor
• CAS No. 867160-71-2
• Calculated MW 421.49
• Formulation C26H23N5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1(O)CC(C1)C1=NC(=C2N1C=CN=C2N)C1=CC2=C(C=C1)C=CC(=N2)C1=CC=CC=C1
  Pathways:Others; Tyrosine Kinase/Adaptors
  Receptor:IGF-1R; Insulin Receptor; IRR
  Boling pt:
  Melting pt:
  Solubility:DMSO:84 mg/mL (199.29 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Mulvihill MJ, et al. Future Med Chem, 2009, 1(6), 1153-1171.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting