• Product NameVolasertib (BI 6727)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityVolasertib (BI 6727) is a highly potent Plk1 inhibitor with IC50 of 0.87 nM. It shows 6- and 65-fold greater selectivity against Plk2 and Plk3. Phase 3.
• Target NamePLK inhibitor
• CAS No. 755038-65-4
• Calculated MW 618.81
• Formulation C34H50N8O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C
  Pathways:Cell Cycle/Checkpoint
  Receptor:PLK1
  Boling pt:
  Melting pt:
  Solubility:DMSO:20 mg/mL warmed (32.32 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Rudolph D, et al. Clin Y Res, 2009, 15(9), 3094-3102.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting