• Product NameGSK1324726A (I-BET726)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityGSK1324726A (I-BET726) is a highly selective inhibitor of BET family proteins with IC50 of 41 nM, 31 nM, and 22 nM for BRD2, BRD3, and BRD4, respectively.
• Target NameEpigenetic Reader Domain inhibitor
• CAS No. 1300031-52-0
• Calculated MW 434.91
• Formulation C25H23ClN2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@H]1C[C@H](C2=C(N1C(=O)C)C=CC(=C2)C3=CC=C(C=C3)C(=O)O)NC4=CC=C(C=C4)Cl
  Pathways:Chromatin/Epigenetic
  Receptor:BRD2; BRD3; BRD4
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 86 mg/mL (197.74 mM); DMSO: 86 mg/mL (197.74 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wyce A, et al. PLoS One. 2013, 8(8), e72967.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting