• Product NameLY404039
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLY404039 is a potent agonist of recombinant human mGlu2/mGlu3 receptors with Ki of 149 nM/92 nM, shows >100-fold selectivity over ionotropic glutamate receptors, glutamate transporters, and other receptors. Phase 3.
• Target NameGlucocorticoid Receptor agonist; GluR agonist
• CAS No. 635318-11-5
• Calculated MW 235.22
• Formulation C7H9NO6S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:C1[C@]([C@@H]2[C@H]([C@@H]2S1(=O)=O)C(=O)O)(C(=O)O)N
  Pathways:Endocrinology/Hormones; Neuroscience
  Receptor:Recombinant human mGlu2; Recombinant human mGlu3; Rat neurons expressing native mGlu2/3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 1 mg/mL (4.25 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Rorick-Kehn LM et al. J Pharmacol Exp Ther, 2007, 321(1), 308-317.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting