• Product NameCH5183284 (Debio-1347)
• Brief DescriptionInhibitors
• Purification95.28%
• Biological ActivityCH5183284 is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Phase 1.
• Target NameFGFR inhibitor
• CAS No. 1265229-25-1
• Calculated MW 356.38
• Formulation C20H16N6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=NC2=C(N1)C=C(C=C2)N1N=CC(C(=O)C2=CC3=CC=CC=C3N2)=C1N
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:FGFR1; FGFR2; FGFR3; FGFR4
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 1 mg/mL warmed (2.8 mM); DMSO: 71 mg/mL (199.22 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Nakanishi Y, et al. Mol Y Ther. 2014, 13(11), 2547-2558.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting