• Product NameDanoprevir (ITMN-191)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityDanoprevir(ITMN-191) is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM, inhibition effect for HCV genotypes 1A/1B/4/5/6 is ~10-fold higher than 2B/3A. Phase 2.
• Target NameHCV Protease inhibitor
• CAS No. 850876-88-9
• Calculated MW 731.83
• Formulation C35H46FN5O9S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)(C)OC(=O)N[C@H]1CCCCC/C=C\[C@@H]2C[C@]2(NC(=O)[C@@H]3C[C@H](CN3C1=O)OC(=O)N4CC5=C(C4)C(=CC=C5)F)C(=O)NS(=O)(=O)C6CC6
  Pathways:Microbiology&virology; Proteases/Proteasome
  Receptor:HCV NS3/4A protease
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 144 mg/mL (196.76 mM); DMSO: 144 mg/mL (196.76 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Seiwert SD, et al. Antimicrob Agents Chemother, 2008, 52(12), 4432-4441.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting