• Product NameXL388
• Brief DescriptionInhibitors
• Purification99.53%
• Biological ActivityXL388 is a highly potent, selective, ATP-competitive inhibitor of mTOR with IC50 of 9.9 nM, 1000-fold selectivity over the closely related PI3K kinases.
• Target NamemTOR inhibitor; P450 inhibitor; PI3K inhibitor
• CAS No. 1251156-08-7
• Calculated MW 455.5
• Formulation C23H22FN3O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(C=CC(=C1F)S(C)(=O)=O)C(=O)N1CCOC2=C(C1)C=C(C=C2)C1=CN=C(N)C=C1
  Pathways:Metabolism; PI3K/Akt/mTOR signaling
  Receptor:mTOR; mTORC1; mTORC2; CYP2C9; PI3Kα
  Boling pt:
  Melting pt:
  Solubility:DMSO: 23 mg/mL (50.49 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Nicole Miller, et al. Mol Y Ther, 2009, 8(12 Suppl):B146.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting