• Product NameOTX015
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityOTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4. Phase 1.
• Target NameEpigenetic Reader Domain inhibitor
• CAS No. 202590-98-5
• Calculated MW 491.99
• Formulation C25H22ClN5O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=NN=C2[C@H](CC(=O)NC3=CC=C(O)C=C3)N=C(C3=C(SC(C)=C3C)N12)C1=CC=C(Cl)C=C1 |r,c:15,18,24,36,t:1,3,10,12,20,31,33|
  Pathways:Chromatin/Epigenetic
  Receptor:BRDs
  Boling pt:
  Melting pt:
  Solubility:DMSO:98 mg/mL (199.19 mM)Ethanol:98 mg/mL (199.19 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Noel JK, et al. Mol Cancer Ther. 2013, 12, C244.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting