• Product NameOdanacatib (MK-0822)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityOdanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.
• Target NameCysteine Protease inhibitor
• CAS No. 603139-19-1
• Calculated MW 525.56
• Formulation C25H27F4N3O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)(C[C@@H](C(=O)NC1(CC1)C#N)N[C@@H](C2=CC=C(C=C2)C3=CC=C(C=C3)S(=O)(=O)C)C(F)(F)F)F
  Pathways:Proteases/Proteasome
  Receptor:Cathepsin K (human); Cathepsin K (rabbit)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (190.27 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gauthier JY, et al. Bioorg Med Chem Lett. 2008, 18(3), 923-928.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting