• Product NameTelotristat Etiprate (LX 1606 Hippurate)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityTelotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Phase 3.
• Target NameHydroxylase activator
• CAS No. 11137608-69-5
• Calculated MW 754.15
• Formulation C27H26ClF3N6O3.C9H9NO3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:OC(=O)CNC(=O)C1=CC=CC=C1.CCOC(=O)[C@@H](N)CC1=CC=C(C=C1)C1=CC(O[C@H](C2=CC=C(Cl)C=C2N2C=CC(C)=N2)C(F)(F)F)=NC(N)=N1 |r,c:9,11,23,25,38,42,45,51,54,t:7,21,28,33,35|
  Pathways:Metabolism
  Receptor:Tryptophan hydroxylase
  Boling pt:
  Melting pt:
  Solubility:DMSO:100 mg/mL (132.59 mM)Ethanol:<1 mg/mL (<1 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pappas C, et al. J Clin Oncol 27, 2009 (suppl; abstr e14555).

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting