• Product NameTorin 1
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityTorin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM; exhibits 1000-fold selectivity for mTOR than PI3K.
• Target NameDNA-PK inhibitor; mTOR inhibitor; PI3K inhibitor
• CAS No. 1222998-36-8
• Calculated MW 607.62
• Formulation C35H28F3N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCC(=O)N1CCN(CC1)C1=C(C=C(C=C1)N1C(=O)C=CC2=CN=C3C=CC(=CC3=C12)C1=CC2=CC=CC=C2N=C1)C(F)(F)F
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:DNA-PK; mTOR; mTORC1; mTORC2; p110γ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 2 mg/mL (3.29 mM)
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Thoreen CC, et al, J Biol Chem, 2009, 284(12), 8023-8032.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting