• Product NameGW 441756
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityGW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2.
• Target NameCDK inhibitor; Raf inhibitor; Trk receptor inhibitor
• CAS No. 504433-23-2
• Calculated MW 275.3
• Formulation C17H13N3O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1C=C(C2=CC=CC=C21)/C=C\3/C4=C(C=CC=N4)NC3=O
  Pathways:Cell Cycle/Checkpoint; MAPK; Tyrosine Kinase/Adaptors
  Receptor:CDK2; C-Raf-1; TrkA
  Boling pt:
  Melting pt:
  Solubility:DMSO: 25 mg/mL (90.81 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wood ER, et al. Bioorg Med Chem Lett, 2004, 14(4), 953-957.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting