• Product NameTurofexorate Isopropyl (XL335)
• Brief DescriptionInhibitors
• Purification99.33%
• Biological ActivityTurofexorate Isopropyl (XL335) is a potent, selective FXR agonist with EC50 of 4 nM, highly selective versus other nuclear receptors, such as LXR, PPAR, ER and etc. Phase 1.
• Target NameFXR agonist
• CAS No. 629664-81-9
• Calculated MW 438.47
• Formulation C25H24F2N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular system/ Metabolism
  SMILES:CC(C)OC(=O)C1=CN(CC(C)(C)C2=C1NC1=CC=CC=C21)C(=O)C1=CC(F)=C(F)C=C1
  Pathways:Metabolism
  Receptor:FXR
  Boling pt:
  Melting pt:
  Solubility:DMSO:33 mg/mL (75.26 mM)Ethanol:2 mg/mL (4.56 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Flatt B, et al. J Med Chem, 2009, 52(4), 904-907.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting