• Product NameURMC-099
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityURMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM.
• Target NameAurora Kinase inhibitor; Bcr-Abl inhibitor; CDK inhibitor; c-Met/HGFR inhibitor; DNA Alkylation inhibitor; IGF-1R inhibitor; LRRK2 inhibitor; MEK inhibitor
• CAS No. 1229582-33-5
• Calculated MW 421.54
• Formulation C27H27N5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1CCN(CC2=CC=C(C=C2)C2=CN=C3NC=C(C3=C2)C2=CC3=C(NC=C3)C=C2)CC1
  Pathways:Cell Cycle/Checkpoint; Angiogenesis; Autophagy; DNA Damage/DNA Repair; MAPK; Metabolism; Tyrosine Kinase/AdaptorsChromatin/EpigeneticCytoskeletal SignalingStem Cells
  Receptor:Aurora A; Aurora B; Aurora C; Abl1; CDK1; CDK2; c-Met; DLK; IGF-1R; Insulin Receptor; LRRK2; MEKK2; MLK1; MLK2; MLK3; ROCK1; ROCK2; SGK; SGK1; Lck; Syk; TrkA; TrkB; VEGFR1/FLT1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 84 mg/mL (199.26 mM); DMSO: 84 mg/mL (199.26 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Goodfellow VS, et al. J Med Chem. 2013, 56(20), 8032-8048.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting