• Product NameLY2886721
• Brief DescriptionInhibitors
• Purification99.94%
• Biological ActivityLY2886721 is a BACE inhibitor used for the treatment of Alzheimer's Disease. Phase 1/2.
• Target NameBACE inhibitor
• CAS No. 1262036-50-9
• Calculated MW 390.41
• Formulation C18H16F2N4O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:[H][C@@]12COC[C@@]1(N=C(N)SC2)C1=CC(NC(=O)C2=NC=C(F)C=C2)=CC=C1F |r,c:24,26,28,t:7,13,19,21|
  Pathways:Neuroscience
  Receptor:BACE
  Boling pt:
  Melting pt:
  Solubility:DMSO:9 mg/mL (23.05 mM)Ethanol:<1 mg/mL (<1 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Adru studies, 2012

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting