• Product NameGSK343
• Brief DescriptionInhibitors
• Purification99.32%
• Biological ActivityGSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM, showing 60 fold selectivity against EZH1, and >1000 fold selectivity against other histone methyltransferases.
• Target NameHistone Methyltransferase inhibitor
• CAS No. 1346704-33-3
• Calculated MW 541.69
• Formulation C31H39N7O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCCC1=C(CNC(=O)C2=C3C=NN(C(C)C)C3=CC(=C2)C2=CC(=NC=C2)N2CCN(C)CC2)C(=O)NC(C)=C1
  Pathways:Chromatin/Epigenetic
  Receptor:EZH1; EZH2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 4 mg/mL (7.38 mM); DMSO: 1 mg/mL warmed (1.84 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Verma SK, et al. ACS Med Chem Lett. 2012, 3, 1091-1096.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting