• Product NameLY411575
• Brief DescriptionInhibitors
• Purification99.38%
• Biological ActivityLY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with IC50 of 0.39 nM.
• Target NameGamma-secretase inhibitor
• CAS No. 209984-57-6
• Calculated MW 479.48
• Formulation C26H23F2N3O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O
  Pathways:Neuroscience; Proteases/Proteasome; Stem Cells
  Receptor:Notch S3 cleavage; γ secretase (cell-based); γ secretase (membrane-based)
  Boling pt:
  Melting pt:
  Solubility:DMSO:95 mg/mL (198.13 mM)Ethanol:13 mg/mL (27.11 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wong GT, et al, J Biol Chem, 2004, 279(13), 12876-12882.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting