• Product NameTriciribine
• Brief DescriptionInhibitors
• Purification99.87%
• Biological ActivityTriciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1 with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.
• Target NameAkt inhibitor; HIV Protease inhibitor
• CAS No. 35943-35-2
• Calculated MW 320.3
• Formulation C13H16N6O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1N=C(N)C2=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C3=C2C1=NC=N3 |r,c:18,24,t:2,5,22|
  Pathways:Cytoskeletal Signaling; Microbiology&virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
  Receptor:Akt; HIV-1
  Boling pt:
  Melting pt:
  Solubility:DMSO:64 mg/mL (199.81 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gursel DB, et al, Nero Oncol, 2011, 13(6), 610-621.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting