• Product NameRigosertib (ON-01910)
• Brief DescriptionInhibitors
• Purification99.37%
• Biological ActivityRigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Phase 3.
• Target NamePLK inhibitor
• CAS No. 1225497-78-8
• Calculated MW 473.47
• Formulation C21H24NNaO8S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
  Pathways:Cell Cycle/Checkpoint
  Receptor:PLK1
  Boling pt:
  Melting pt:
  Solubility:Water: 95 mg/mL (200.64 mM); DMSO: 95 mg/mL (200.64 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gumireddy K, et al. Y Cell, 2005, 7(3), 275-286.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting